BEIJING. August 24. KAZINFORM An experimental vaccine appears to be safe and effective in protecting people against hepatitis E infection, a trial in China has found, Kazinform refers to Xinhua.

Hepatitis E virus is shed in feces and spread via tainted water and food.

Even though most people recover, it can cause severe illness in elderly people and has a mortality rate of 1 to 3 percent.

The virus can kill between 5 to 25 percent of pregnant women and those who survive can suffer high rates of miscarriage.

In a phase 3 trial involving 97,356 healthy participants in east China's Jiangsu Province, half were given the China-made vaccine and the other half placebo.

The vaccine made by Xiamen Innovax Biotech was given in three doses. The second was given after a month; the third was given after six months.

Within a year after the third dose, 15 of the participants who were given placebo were found infected with hepatitis E, the researchers said in a paper published in The Lancet yesterday.

No one in the vaccine group was infected.

"In our trial, we found the vaccine well tolerated and efficacious for a general adult population.

"Further studies are needed to assess the safety and to support the benefits of the vaccine for pregnant women and for people younger than 15 years or older than 65 years," the researchers wrote in a statement.

"During a hepatitis E outbreak, or for travelers to an endemic area, protection can be quickly obtained by two vaccine doses given within one month."

No serious side effects were found to be linked to the vaccine, they said.

The researchers were led by Xia Ningshao at the Institute of Diagnostics and Vaccine Development in Infectious Diseases in Xiamen University in the southern Fujian Province, Kazinform cites Xinhua. See www.xinhaunet.com for full version.